Serex Inc., Nymox's Majority-Owned Subsidiary

In March, 2000, Nymox acquired a controlling interest in Serex, Inc., a privately held diagnostic company. Serex is based in Hasbrouck Heights, New Jersey.

Serex developed and patented its particle valence technology, a unique, highly sensitive, new method to detect very small amounts of biochemical indicators in body fluids such as blood, urine and saliva. This technology can enable the easy and rapid testing of samples by general-purpose medical laboratories or in doctors' offices.

Serex's diagnostic technology can be adapted to detect a wide range of biochemical indicators for diseases, conditions and drug use. This technology was used to develop products to detect and measure levels of tobacco exposure or use. Nymox markets NicAlert™ and TobacAlert™ which are easy-to-use on-site products for detecting and measuring tobacco exposure or use. Both products employ Serex's patented technology to provide semi-quantitative measurements of levels of cotinine, one of the metabolic products of nicotine and a widely used marker of tobacco exposure. In early stage development are a number of tests, including a test that can detect biochemical indicators of cholesterol in human saliva and therefore provide an inexpensive, convenient and reliable method of determining and monitoring cholesterol levels. Preliminary work was done on tests designed to detect indicators for heart disease and for blood sugar levels in a type of diabetes and to monitor therapeutic drug levels.

Serex also has patents for diagnostic biochemical indicators of osteoporosis and cholesterol levels. In October 2004, Serex was granteded a U.S. patent for a unique method and device for measuring levels of biochemical indicators in saliva in order to determine cholesterol levels. In November, 1999, Serex was granted a United States patent for an antibody and for the use of the antibody in its technology in order to detect one of the biochemical indicators for the loss of bone matter, which is a sign of osteoporosis, the most common bone disease in people. Osteoporosis results from the progressive loss of bone material and can cause disabling and potentially life-threatening bone fractures in particular of the spine and the hips. It is most common in the elderly and in post-menopausal women.